This involve d combining the results of the 34 trials reviewed to derive an overall summary estimate of the effectiveness of each medication across studies.įor this study, the authors were interested in research comparing medications to 1) other medications, 2) placebo treatments, or 3) psychotherapy for adults (i.e., 18+ years) with amphetamine use disorder. Once reviewed, the authors performed a m eta-analys i s. These 18 articles represented findings from 34 clinical trials, with samples ranging from 19 to 229 patients. They identified 369 relevant articles for full review, and 18 of these articles satisfied eligibility criteria. The initial search included 5,936 articles. HOW WAS THIS STUDY CONDUCTED?įor this study, the authors conducted a systematic review and meta-analysis of randomized controlled trials of adults with amphetamine use disorder that tested medications against other medications, placebo, or psychotherapy. The authors of th e current study reviewed dozens of articles on the topic to provide a summary of 1) medications studied to date, 2) the effectiveness and strength of the evidence supporting their use in treatment, and 3) recommendations for where we should go from here. Fortunately, researchers continue to work toward developing and evaluating medications to help treat this disorder. However, the results of these studies are varied, and the methods used to test these treatments have limitations. Numerous medications have been tested to see whether they can help reduce amphetamine use and improve study/ treatment retention and recovery. ![]() However, u nlike opioid use disorder, there are no FDA-approved medication s for amphetamine use disorder. ![]() In the background of the ongoing opioid crisis, rates of methamphetamine/amphetamine (henceforth “amphetamine”) use and associated overdose deaths are rising. This study reviews existing evidence for several medication classes and offers future directions. There are currently no FDA-approved medications for methamphetamine or amphetamine use disorders, yet there are some promising medication candidates. Printed by the Authority of the State of Illinois.While medications show promise, those effective for amphetamine use disorder are few and far between The department is an equal opportunity employer and practices affirmative action and reasonable accommodation programs.ĭHS 4490 (R-03-14) Drug Series - Amphetamines Visit our web site at: Programs, activities and employment opportunities in the Illinois Department of Human Services are open and accessible to any individual or group without regard to age, sex, race, sexual orientation, disability, ethnic origin or religion. Monday - Friday (except state holidays) For answers to your questions, you may also write:īureau of Customer and Provider Assistance You may speak to a representative between: 8:00 a.m. If you do not know where your FCRC is or if you are unable to go there, you may call the automated helpline 24 hours a day at: If you have questions about any Illinois Department of Human Services (IDHS) program, call or visit your FCRC. If you have any questions about alcohol or other drugs, call:ĭivision of Alcoholism and Substance Abuse If you would like to know what substance abuse treatment providers are in your community, contact one of the following helplines: SUBSTANCE ABUSE TREATMENT FACILITY LOCATOR They are often associated with violence and anti-social behavior. THE LOW:Īmphetamines can trigger a number of unpleasant, sometimes deadly effects. The high is usually followed by intense mental depression and fatigue. This high is long lasting compared to other drugs and can often linger for 8 to 24 hours. It induces exhilarating feelings of power, strength, energy, self-assertion, focus, and enhanced motivation. The drug can fight fatigue and allow people to work around the clock. Slang Terms:Īmphetamines increase energy and produce a sense of pleasure and peace. Amphetamines are often used illegally to avoid sleep, improve athletic performance, or counter the effects of depressant drugs. ![]() ![]() These drugs may be used medically to treat depression, obesity, and other conditions. Amphetamines are drugs that are stimulants to the central nervous system.
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